生物
类有机物
诱导多能干细胞
肾脏发育
肾
器官发生
再生(生物学)
计算生物学
生物信息学
细胞生物学
胚胎干细胞
遗传学
基因
作者
Melissa H. Little,Alexander N. Combes
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory]
日期:2019-10-01
卷期号:33 (19-20): 1319-1345
被引量:120
标识
DOI:10.1101/gad.329573.119
摘要
There are now many reports of human kidney organoids generated via the directed differentiation of human pluripotent stem cells (PSCs) based on an existing understanding of mammalian kidney organogenesis. Such kidney organoids potentially represent tractable tools for the study of normal human development and disease with improvements in scale, structure, and functional maturation potentially providing future options for renal regeneration. The utility of such organotypic models, however, will ultimately be determined by their developmental accuracy. While initially inferred from mouse models, recent transcriptional analyses of human fetal kidney have provided greater insight into nephrogenesis. In this review, we discuss how well human kidney organoids model the human fetal kidney and how the remaining differences challenge their utility.
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