三阴性乳腺癌
癌症研究
转移
血管生成
乳腺癌
癌变
癌症
医学
靶向治疗
细胞凋亡
细胞周期
细胞生长
肿瘤科
内科学
化学
生物化学
作者
Haonan Li,Fanxing Xu,Gang Gao,Xiang Gao,Bo Wu,Chao Zheng,Peng Wang,Zhan‐Lin Li,Hui‐Ming Hua,Dahong Li
出处
期刊:Redox biology
[Elsevier]
日期:2020-07-01
卷期号:34: 101564-101564
被引量:60
标识
DOI:10.1016/j.redox.2020.101564
摘要
Hydrogen sulfide (H2S) is considered as a novel second-messenger molecule associated with the modulation of various physiological and pathological processes. In the field of antitumor research, endogenous H2S induces angiogenesis, accelerates the cell cycle and inhibits apoptosis, which results in promoting oncogenesis eventually. Interestingly, high concentrations of exogenous H2S liberated from donors suppress the growth of various tumors via inducing cellular acidification and modulating several signaling pathways involved in cell cycle regulation, proliferation, apoptosis and metastasis. The selective release of certain concentrations of H2S from H2S donors in the target has been considered as an alternative tumor therapy strategy. Triple-negative breast cancer (TNBC), an aggressive subtype with less than one year median survival time, is known to account for approximately 15–20% of all breast cancers. Due to the lack of approved targeted therapy, the clinical treatment of TNBC is still hindered by metastasis as well as recurrence. Significant efforts have been spent on developing novel treatments of TNBC, and remarkable progress in the control of TNBC by H2S donors and their derivatives have been made in recent years. This review summarizes various pathways involved in antitumor and anti-metastasis effects of H2S donors and their derivatives on TNBC, which provides novel insights for TNBC treatment.
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