亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Comparison of Characteristics and Outcomes of Patients With Heart Failure With Preserved Ejection Fraction With Versus Without Hyperuricemia or Gout

高尿酸血症 痛风 医学 射血分数保留的心力衰竭 内科学 危险系数 心力衰竭 心脏病学 尿酸 射血分数 置信区间
作者
Anthony P. Carnicelli,Robert Clare,Karen Chiswell,Barbara L. Lytle,Magnus K. Bjursell,Shira Perl,Karolina Sundell Andersson,Katarina Hedman,Neha J. Pagidipati,Sreekanth Vemulapalli,Matthew T. Roe,Robert J. Mentz
出处
期刊:American Journal of Cardiology [Elsevier BV]
卷期号:127: 64-72 被引量:8
标识
DOI:10.1016/j.amjcard.2020.04.026
摘要

Hyperuricemia and gout are common in patients with heart failure (HF) and are associated with poor outcomes. Data describing hyperuricemia and gout in patients with HF with preserved ejection fraction (HFpEF) are limited. We used data from the Duke University Health System to describe characteristics of patients with HFpEF and hyperuricemia (serum uric acid >6 mg/dl) or gout (gout diagnosis or gout medication within the previous year) and to explore associations with 5-year outcomes (death and hospitalization). We identified 7,004 patients in the Duke University Health System with a known diagnosis of HFpEF who underwent transthoracic echocardiography between January 1, 2005 and December 31, 2017. A total of 1,136 (16.2%) patients with HFpEF also had hyperuricemia or gout. Patients with HFpEF and hyperuricemia or gout had a greater co-morbidity burden, more echocardiographic findings of cardiac remodeling, and higher unadjusted rates of all-cause death, all-cause hospitalization, and HF hospitalization compared with those with HFpEF without hyperuricemia or gout. After multivariable adjustment, patients with HFpEF and hyperuricemia or gout had a significantly higher rates of first all-cause hospitalization (adjusted hazard ratio 1.10 [95% confidence interval 1.02 to 1.19]; p = 0.020) and recurrent all-cause hospitalization (associated rate ratio 1.13 [95% confidence interval 1.01 to 1.25]; p = 0.026). After adjustment, no significant differences in death or HF hospitalization were observed. In conclusion, patients with HFpEF and hyperuricemia or gout were found to have a higher burden of co-morbidities and a higher rate of all-cause hospitalization, even after multivariable adjustment, compared to patients with HFpEF without hyperuricemia or gout. Hyperuricemia and gout are common in patients with heart failure (HF) and are associated with poor outcomes. Data describing hyperuricemia and gout in patients with HF with preserved ejection fraction (HFpEF) are limited. We used data from the Duke University Health System to describe characteristics of patients with HFpEF and hyperuricemia (serum uric acid >6 mg/dl) or gout (gout diagnosis or gout medication within the previous year) and to explore associations with 5-year outcomes (death and hospitalization). We identified 7,004 patients in the Duke University Health System with a known diagnosis of HFpEF who underwent transthoracic echocardiography between January 1, 2005 and December 31, 2017. A total of 1,136 (16.2%) patients with HFpEF also had hyperuricemia or gout. Patients with HFpEF and hyperuricemia or gout had a greater co-morbidity burden, more echocardiographic findings of cardiac remodeling, and higher unadjusted rates of all-cause death, all-cause hospitalization, and HF hospitalization compared with those with HFpEF without hyperuricemia or gout. After multivariable adjustment, patients with HFpEF and hyperuricemia or gout had a significantly higher rates of first all-cause hospitalization (adjusted hazard ratio 1.10 [95% confidence interval 1.02 to 1.19]; p = 0.020) and recurrent all-cause hospitalization (associated rate ratio 1.13 [95% confidence interval 1.01 to 1.25]; p = 0.026). After adjustment, no significant differences in death or HF hospitalization were observed. In conclusion, patients with HFpEF and hyperuricemia or gout were found to have a higher burden of co-morbidities and a higher rate of all-cause hospitalization, even after multivariable adjustment, compared to patients with HFpEF without hyperuricemia or gout.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
towerman发布了新的文献求助10
3秒前
上官若男应助研友_qZ6V1Z采纳,获得10
7秒前
FengyaoWang完成签到,获得积分10
7秒前
8秒前
enchanted发布了新的文献求助10
13秒前
ZHANG123完成签到,获得积分10
17秒前
24秒前
七色光完成签到,获得积分10
25秒前
26秒前
26秒前
ceeray23发布了新的文献求助20
29秒前
爆米花应助Bowman采纳,获得30
32秒前
33秒前
研友_qZ6V1Z发布了新的文献求助10
38秒前
38秒前
shaylie完成签到 ,获得积分10
38秒前
伽拉发布了新的文献求助10
39秒前
轻松的惜芹应助linkman采纳,获得10
41秒前
Karol发布了新的文献求助10
41秒前
42秒前
hhw发布了新的文献求助10
42秒前
46秒前
充电宝应助hhw采纳,获得10
51秒前
霜鸣发布了新的文献求助10
51秒前
热爱科研的小白鼠完成签到,获得积分10
51秒前
还单身的心情完成签到 ,获得积分10
56秒前
研友_qZ6V1Z发布了新的文献求助10
56秒前
轻松的惜芹应助linkman采纳,获得10
57秒前
慕青应助我爱物理采纳,获得10
1分钟前
1分钟前
充电宝应助霜鸣采纳,获得10
1分钟前
1分钟前
隐形曼青应助伽拉采纳,获得10
1分钟前
hhw完成签到,获得积分10
1分钟前
咕噜噜发布了新的文献求助10
1分钟前
1分钟前
1分钟前
研友_qZ6V1Z发布了新的文献求助10
1分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990012
求助须知:如何正确求助?哪些是违规求助? 3532049
关于积分的说明 11256153
捐赠科研通 3270925
什么是DOI,文献DOI怎么找? 1805123
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809216