Falsely Elevated Serum Creatinine Associated With IgM Paraproteinemia

The serum creatinine level is one of the widely used indices for estimating renal function and is used in some equations to calculate the estimated glomerular filtration rate (eGFR).1,2 Two methods, namely the Jaffe method and the enzymatic method, are widely used for measuring creatinine levels. Creatinine measurement with the enzymatic method is less susceptible to interference by glucose or bilirubin and has a smaller coefficient of variance, resulting in more accurate staging of chronic kidney disease than the Jaffe method.