Objective: To explore the interaction of health literacy and second-hand smoke exposure on psychopathological symptoms of middle school students. Methods: From November 2015 to January 2016, 22 628 middle school students from Shenyang of Liaoning Province, Bengbu of Anhui Province, Xinxiang of Henan Province, Ulanqab of Inner Mongolia Autonomous Region, Chongqing Municipality, and Yangjiang of Guangdong Province were enrolled by using the multi-stage cluster convenience sampling method. A questionnaire was used to collect the data including demographic information, health literacy, second-hand smoke exposure, and psychopathological symptoms. A multivariate logistic regression model was used to analyze the interaction of health literacy and second-hand smoke exposure on psychopathological symptoms of middle school students. Results: The age of students was (15.36±1.79) years old, of which 10 990 were boys, accounting for 48.6% of total students. The detection rate of psychopathological symptoms was 29.1% (6 581/22 628). The detection rate of psychopathological symptoms in those who were exposed to second-hand smoke was 38.1% (2 401/6 304), which was higher than that in the non-second-hand smoke exposure group [25.6% (4 180/16 324)] (P<0.001). The OR (95%CI) of the interaction between medium and low levels of overall health literacy, low level of interpersonal dimension of health literacy and second-hand smoke exposure was 1.19 (1.15-1.24), 2.00 (1.92-2.10) and 1.59 (1.52-1.66), respectively. Conclusion: There was a positive interaction between middle and low levels of overall health literacy, low level of interpersonal dimension of health literacy and second-hand smoke exposure on psychopathological symptoms of middle school students.目的: 探讨健康素养和二手烟暴露对中学生心理病理症状的交互作用。 方法: 2015年11月至2016年1月采用多阶段整群方便抽样方法,在辽宁沈阳、安徽蚌埠、河南新乡、内蒙古乌兰察布、重庆和广东阳江等6个城市抽取22 628名中学生进行问卷调查,调查基本情况、健康素养、二手烟暴露及心理病理症状等。采用多因素logistic回归模型分析健康素养和二手烟暴露对中学生心理病理症状的交互作用。 结果: 调查对象年龄为(15.36±1.79)岁,其中男生10 990名,占48.6%。调查对象心理病理症状检出率为29.1%(6 581/22 628)。二手烟暴露者心理病理症状检出率为38.1%(2 401/6 304),高于无二手烟暴露者[25.6%(4 180/16 324)](P<0.001)。总体健康素养中、低水平,健康素养人际关系维度低水平与二手烟暴露的交互作用项的OR(95%CI)值分别为1.19(1.15~1.24)、2.00(1.92~2.10)和1.59(1.52~1.66)。 结论: 总体健康素养中、低水平,健康素养人际关系维度低水平均与二手烟暴露对中学生心理病理症状发生存在正交互作用。.