明胶
生物相容性
材料科学
生物医学工程
自愈水凝胶
体内
剪切减薄
脚手架
化学工程
流变学
复合材料
化学
高分子化学
生物化学
生物技术
医学
冶金
工程类
生物
作者
Chengbin Xue,Huifang Xie,James Eichenbaum,Yi Chen,Yonggang Wang,Floor W. van den Dolder,Junmin Lee,KangJu Lee,Shiming Zhang,Wujin Sun,Amir Sheikhi,Samad Ahadian,Nureddin Ashammakhi,Mehmet R. Dokmeci,Han‐Jun Kim,Ali Khademhosseini
标识
DOI:10.1002/biot.201900456
摘要
Abstract Injectable shear‐thinning biomaterials (iSTBs) have great potential for in situ tissue regeneration through minimally invasive therapeutics. Previously, an iSTB was developed by combining gelatin with synthetic silicate nanoplatelets (SNPs) for potential application to hemostasis and endovascular embolization. Hence, iSTBs are synthesized by varying compositions of gelatin and SNPs to navigate their material, mechanical, rheological, and bioactive properties. All compositions (each component percentage; 1.5–4.5%/total solid ranges; 3–9%) tested are injectable through both 5 Fr general catheter and 2.4 Fr microcatheter by manual pressure. In the results, an increase in gelatin contents causes decrease in swellability, increase in freeze‐dried hydrogel scaffold porosity, increase in degradability and injection force during iSTB fabrication. Meanwhile, the amount of SNPs in composite hydrogels is mainly required to decrease degradability and increase shear thinning properties of iSTB. Finally, in vitro and in vivo biocompatibility tests show that the 1.5–4.5% range gelatin–SNP iSTBs are not toxic to the cells and animals. All results demonstrate that the iSTB can be modulated with specific properties for unmet clinical needs. Understanding of mechanical and biological consequences of the changing gelatin–SNP ratios through this study will shed light on the biomedical applications of iSTB on specific diseases.
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