雌激素
更年期
内科学
内分泌学
医学
动脉硬化
激素
脂肪组织
代谢综合征
激素替代疗法(女性对男性)
疾病
睾酮(贴片)
肥胖
生理学
作者
Hizuru Yamatani,Kazuhiro Takahashi,Satoru Nagase
出处
期刊:PubMed
日期:2015-04-01
卷期号:73 (4): 565-70
被引量:1
摘要
Sex hormones as estrogen, testosterone, dehydroepiandrosterone decline with age. Especially in women, bioavailable estrogen level rapidly decreases around the menopause. Estrogen acts against arteriosclerosis to vascular endothelial cells and vascular smooth muscle cells. The lack of estrogen with menopause accelerates arteriosclerosis that is the leading cause of cardiovascular diseases. The adipose distribution shifts from gluteo-femoral to abdominal depots after menopause, and it is well known that visceral obesity induce metabolic syndrome, which is also high risk state for cardiovascular disease. Estrogen replacement therapy may reduce the cardiovascular risk, and we should pay attention to the starting age of women who undergo hormone therapy.
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