磺酰
化学
催化作用
钴
环异构化
烷基
芳基
乙醚
溶剂
药物化学
磺胺
有机化学
转化(遗传学)
组合化学
生物化学
基因
作者
David Fischer,Moritz Balkenhohl,Erick M. Carreira
出处
期刊:JACS Au
[American Chemical Society]
日期:2022-05-06
卷期号:2 (5): 1071-1077
被引量:10
标识
DOI:10.1021/jacsau.2c00186
摘要
The cycloisomerization of β-, γ-, and δ-unsaturated N-acyl sulfonamides to N-sulfonyl lactams and imidates is reported. This transformation is effected in the presence of a CoIII(salen) catalyst using t-BuOOH or air as the oxidant. The method shows good functional group tolerance (alkyl, aryl, heteroaryl, ether, N-Boc) and furnishes an underexplored class of cyclic building blocks. The strong solvent dependence of the transformation is investigated, and the synthetic versatility of the N-sulfonyl imidate product class is highlighted.
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