医学
节奏
心房颤动
临床试验
不利影响
内科学
心脏病学
重症监护医学
作者
Sherif Roman,Kevin Patel,David Hana,K.C. Guice,Jay Patel,Christopher Stadnick,Amir Basta,Rami N. Khouzam
出处
期刊:Future Cardiology
[Future Medicine]
日期:2022-04-01
卷期号:18 (4): 354-353
被引量:3
标识
DOI:10.2217/fca-2021-0034
摘要
The clinical choice between rate or rhythm control therapies has been debated over the years. In 2002, the AFFIRM trial demonstrated that the rhythm-control strategy had no survival advantage over the rate-control strategy. Eighteen years later, EAST-AFNET 4 showed that the rhythm-control approach is better than rate control in reducing adverse cardiovascular outcomes in patients with a recent diagnosis of atrial fibrillation (AF). During the time between AFFIRM and EAST-AFNET 4, rhythm control understanding, specifically ablation, improved, while rate-control strategies remained the same possibly leading to the change in results seen in EAST-AFNET 4. This review seeks to evaluate the rate- and rhythm-control strategies, focusing on the important clinical trials in the past two decades. These trials have shown great advancement in AF management; however, the search for the best approach to controlling AF and minimizing the burden of symptoms is still a work in progress and needs further research.
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