光热治疗
光动力疗法
材料科学
纳米技术
生物相容性
生物医学工程
计算机科学
化学
医学
有机化学
冶金
作者
Jie Wang,Fernando Soto,Shiqin Liu,Qingqing Yin,Emma Purcell,Yitian Zeng,En‐Chi Hsu,Demir Akin,Bob Sinclair,Tanya Stoyanova,Utkan Demirci
标识
DOI:10.1002/adfm.202201800
摘要
Abstract Biohybrid microrobotics are exploited as a delivery approach to actively transport therapeutic payload to tumors. However, the therapeutic utility of this approach can be diminished by tumor hypoxia. Moreover, current biohybrid microrobotics design is mainly focused on the living organisms’ motility and biocompatibility, yet the unique biological function of the natural organism is often overlooked. Here, an all‐in‐one self‐propelled volvox‐based multifunctional robot, that is, Volbot, with built‐in capabilities of fluid mixing, multimode imaging, and photosynthesis‐mediated in situ oxygen generation that can potentially relieve hypoxia is developed. Volbots can follow a pre‐specified route and directionality under the control of a magnetic field. Red‐light irradiation (λ = 650 nm) can enhance the Volbot's locomotive behavior, enhance the mixing of biofluids, and modulate the oxygen production to improve the efficacy of photodynamic therapy. Moreover, Volbots can absorb near‐infrared irradiation and produce localized hyperthermia to treat tumors. Subcutaneous tumor suppression can be achieved by this high‐yield oxygen‐producing biohybrid “microfactory” in a photodynamic/photothermal‐synergistic therapy strategy. Furthermore, Volbots also offer imaging capabilities and exhibit considerable promise as a multifunctional microrobotics‐based theranostic approach for a precision tumor therapy strategy.
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