光热治疗
材料科学
纳米颗粒
纳米技术
生物医学中的光声成像
药物输送
生物相容性材料
生物医学工程
光学
医学
物理
作者
Xin Ding,Tianyu Wang,Shiwei Bai,Yunfeng Wan,Shuai Zhu,Tao Li,Na Peng,Tao Qiu,Yi Liu
标识
DOI:10.1021/acsami.2c07671
摘要
Multifunctional nanoparticles (NPs) with simultaneous multimodal therapeutic and imaging capabilities are very necessary for biomedical applications. We successfully prepared bowl-shaped gold@polydopamine yolk-shell NPs (bowl-shaped Au@PDA YNPs) by a novel and facile method. The unique bowl-like structure enables a drug loading rate of 92% (920 μg mg-1). The bowl-shaped Au@PDA YNPs are biocompatible, have good photothermal conversion and strong near-infrared (NIR) absorption, and can control drug release under pH/NIR dual response. Bowl-shaped Au@PDA YNPs can also be employed as contrast agents for computed tomography/photoacoustic imaging for dual-modal imaging-guided chemotherapy and photothermal therapy due to the presence of Au NPs.
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