医学
肌萎缩
四分位间距
改良兰金量表
冲程(发动机)
前瞻性队列研究
物理疗法
日常生活活动
逻辑回归
队列研究
内科学
队列
缺血性中风
机械工程
工程类
缺血
作者
Masafumi Nozoe,Madoka Noguchi,Hiroki Kubo,Masashi Kanai,Shinichi Shimada
摘要
Aim To investigate the effects of coexisting conditions such as premorbid sarcopenia, frailty, and disability on functional outcomes in older patients with acute stroke. Methods This prospective cohort study included older patients (aged ≥65 years) hospitalized for acute stroke at a single neurosurgical hospital. Premorbid sarcopenia, frailty, and disability were diagnosed using the strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC-F) questionnaire, frailty index, and modified Rankin Scale (mRS) on admission. The primary outcome was the mRS score 3 months after stroke, and a poor outcome was defined as mRS ≥4. Results This study included 317 older patients with acute stroke (median [interquartile range] age: 76 [12] years). Premorbid sarcopenia, frailty, and disability (mRS = 2 or 3) were identified in 59 (19%), 27 (9%), and 54 (17%) patients, respectively. Two coexisting conditions were observed in 26 patients (8%), and three were observed in 18 patients (6%). Adjusted logistic regression analysis revealed that coexisting conditions were independently associated with poor outcomes (one condition, adjusted OR: 3.20 [95%CI: 0.98–10.45]; two conditions, adjusted OR: 6.57 [95%CI: 1.74–24.87]; three conditions, adjusted OR: 12.70 [95%CI: 2.65–60.91]). Conclusions The coexistence of premorbid sarcopenia, frailty, and disability was associated with poor functional outcomes in older patients with acute stroke. Geriatr Gerontol Int 2022; 22: 642–647.
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