脱氮酶
泛素
降级(电信)
化学
细胞凋亡
癌症研究
组合化学
细胞生物学
生物
计算机科学
生物化学
电信
基因
作者
Arunima Murgai,Izidor Sosič,Martina Gobec,Patricia Lemnitzer,Matic Proj,Sophie Wittenburg,Rabea Voget,Michael Gütschow,Jan Krönke,Christian Steinebach
摘要
A novel class of USP7 PROTACs were designed and synthesized. CST967, a CRBN-based degrader, showed potent and selective depletion of USP7 leading to apoptosis in multiple cancer lines.
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