Revisiting the impact of serial therapeutic phlebotomy in polycythaemia on laboratory and clinical parameters using a fixed interval and fixed volume protocol

静脉切开术 红细胞增多症 红细胞压积 医学 血容量 放血 真性红细胞增多症 可视模拟标度 外科 麻醉 内科学 病理 替代医学
作者
Siddharth Bhatia,Paramjit Kaur,Gagandeep Kaur,Anita Tahlan,Varinder Saini,Ravneet Bedi,Kshitija Mittal,Tanvi Sood
出处
期刊:Transfusion Clinique Et Biologique [Elsevier BV]
标识
DOI:10.1016/j.tracli.2022.07.003
摘要

Therapeutic phlebotomy allows for a controlled and gradual decrease in red cell mass leading to improved blood flow and symptomatic relief in polycythaemia. The present study was aimed to determine the impact of serial fixed volume and fixed interval therapeutic phlebotomy protocol on the laboratory and clinical parameters in patients of polycythaemia.This prospective longitudinal study was conducted over 18 months. The desired haematocrit for polycythemia vera and secondary polycythemia was 45% and 52% respectively. A fixed volume of 350 ml phlebotomy was performed every-three days till the achievement of desired haematocrit. Complete blood count was performed before and after each procedure and iron studies were done at the time of enrolment and after the achievement of desired haematocrit. Post-procedure symptomatic relief was assessed by a 10-point visual analogue scale (VAS).Of the 29 patients enrolled in the study, 3 patients were lost to follow up and data of 26 patients was analyzed. Mean Hb declined from 17.84 ± 1.88 gdL-1 to 14.67 ± 1.14 gdL-1 (p < 0.001) and mean haematocrit decreased from a baseline of 57.11 ± 5.47% to 46.27 ± 3.763% (p < 0.001) upon achievement of desired haematocrit. There was a significant decline in serum iron from the baseline of 132.85 ± 94.136 μg dL-1 to 69.41 ± 58.643 μg dL-1 at desired haematocrit. A significant change in VAS score of almost all clinical parameters was observed. Post phlebotomy hematocrit correlated negatively with the number of procedures (p = 0.015).Our protocol yielded rapid and marked improvement in patients of primary and secondary polycythemia with minimal adverse events and significant amelioration of clinical parameters.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wxy完成签到,获得积分10
1秒前
2秒前
香蕉觅云应助儒雅南风采纳,获得10
4秒前
郭小宝发布了新的文献求助10
8秒前
情怀应助幸福大白采纳,获得10
8秒前
齐天大圣应助幸福大白采纳,获得30
9秒前
孙燕应助幸福大白采纳,获得30
9秒前
英姑应助幸福大白采纳,获得30
9秒前
9秒前
Hashub完成签到,获得积分20
9秒前
11秒前
xueyu发布了新的文献求助10
13秒前
wonder123发布了新的文献求助10
14秒前
科研通AI2S应助张雯思采纳,获得10
15秒前
15秒前
小二郎应助张雯思采纳,获得10
15秒前
情怀应助张雯思采纳,获得10
15秒前
15秒前
科研通AI2S应助张雯思采纳,获得10
15秒前
今后应助张雯思采纳,获得10
15秒前
在水一方应助张雯思采纳,获得10
15秒前
Jasper应助张雯思采纳,获得10
15秒前
41应助张雯思采纳,获得10
15秒前
15秒前
新xin完成签到,获得积分10
16秒前
儒雅南风发布了新的文献求助10
16秒前
xxddw发布了新的文献求助10
16秒前
33发布了新的文献求助30
16秒前
17秒前
17秒前
Rondab应助科研小白采纳,获得10
18秒前
19秒前
wonder123完成签到,获得积分10
19秒前
量子星尘发布了新的文献求助10
21秒前
幸福的乾发布了新的文献求助10
21秒前
xyj6486发布了新的文献求助10
21秒前
22秒前
小晓发布了新的文献求助10
24秒前
Owen应助伏坎采纳,获得10
27秒前
健壮雨兰完成签到,获得积分10
27秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989444
求助须知:如何正确求助?哪些是违规求助? 3531531
关于积分的说明 11254250
捐赠科研通 3270191
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174