Antibiotic leakage into groundwater and into the natural environments has drawn attention due to their high hazard potential. This chapter addresses the application of three approaches to antibiotic remediation: adsorptive capture, catalytic degradation, and membrane separation. Currently, three main treatment methods are common to address antibiotics-polluted wastewater, namely physical adsorption, advanced oxidation, and polymeric nanofiltration. High aspect ratio MXene nanosheets might be restacked to form such regular galleries for the efficient separation of antibiotics-containing wastewater. Physical adsorption technology can remove antibiotics simply and efficiently from wastewater without forming new highly toxic by-products. Compared to the single filtration or batch e-Fenton process, the e-Fenton oxidation process integrated with a membrane separation technology shows better antibiotics removal efficiency and long-term operation performance. Membrane separation technology, which has a low carbon footprint, provides operation continuity and involves no chemical reactions, has shown promising application potential in antibiotics-contaminated wastewater treatment.