化学
邻苯二甲酸锌
醋酸铵
丙二腈
离子液体
催化作用
微波辐射
有机化学
组合化学
高效液相色谱法
作者
Chetan K. Jadhav,Amol S. Nipate,Asha V. Chate,Makrand V. Kulkarni,Charansingh H. Gill
标识
DOI:10.1080/10406638.2021.2021252
摘要
In the frame of research that examines the use of task-specific ionic liquids (ILs) for developing green methodologies toward bioactive substituted 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives via one-pot condensation of aldehydes, malononitrile and phthalhydrazide presence of Diisopropyl Ethyl Ammonium Acetate (DIPEAc-IL) as catalyst under conventional reflux as well as microwave irradiation condition. providing the desired product in very satisfactory yields (up to 94%) and high purity after simple workup. The task-specific ILs were recycled and reused four times without a noticeable decrease in their catalytic activity. Mild conditions with excellent conversions and simple product isolation procedures are noteworthy advantages of this method. The recyclability of the ionic liquid makes this protocol environmentally benign.
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