外渗
转移
循环肿瘤细胞
癌症研究
医学
血小板
癌细胞
血小板活化
癌症
病理
化学
免疫学
内科学
作者
Longlong Zhang,Yuefei Zhu,Xunbin Wei,Xing Chen,Li Yang,Ying Zhu,Jiaxuan Xia,Yiheng Huang,Yongzhuo Huang,Jianxin Wang,Zhiqing Pang
标识
DOI:10.1016/j.apsb.2022.01.005
摘要
Platelets buoy up cancer metastasis via arresting cancer cells, enhancing their adhesion, and facilitating their extravasation through the vasculature. When deprived of intracellular and granular contents, platelet decoys could prevent metastatic tumor formation. Inspired by these, we developed nanoplatesomes by fusing platelet membranes with lipid membranes (P-Lipo) to restrain metastatic tumor formation more efficiently. It was shown nanoplateletsomes bound with circulating tumor cells (CTC) efficiently, interfered with CTC arrest by vessel endothelial cells, CTC extravasation through endothelial layers, and epithelial-mesenchymal transition of tumor cells as nanodecoys. More importantly, in the mouse breast tumor metastasis model, nanoplateletsomes could decrease CTC survival in the blood and counteract metastatic tumor growth efficiently by inhibiting the inflammation and suppressing CTC escape. Therefore, nanoplatelesomes might usher in a new avenue to suppress lung metastasis.
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