计算生物学
生物
鉴定(生物学)
长非编码RNA
核糖体RNA
小核仁RNA
非编码RNA
核糖核酸
遗传学
基因
植物
作者
Junhong Li,Lei Qu,Lingjie Sang,Xinyu Wu,Anlan Jiang,Jian Liu,Aifu Lin
摘要
Long non-coding RNAs (lncRNAs) transcribed in mammals and eukaryotes were thought to have no protein coding capability. However, recent studies have suggested that plenty of lncRNAs are mis-annotated and virtually contain coding sequences which are translated into functional peptides by ribosomal machinery, and these functional peptides are called micropeptides or small peptides. Here we review the rapidly advancing field of micropeptides translated from putative lncRNAs, describe the strategies for their identification, and elucidate their critical roles in many fundamental biological processes. We also discuss the prospects of research in micropeptides and the potential applications of micropeptides.
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