楔前
失认症
额内侧回
神经科学
后扣带
心理学
舌回
痴呆
海马结构
功能磁共振成像
医学
心脏病学
听力学
认知
内科学
疾病
作者
Shanshan Chen,Yu Song,Huimin Wu,Honglin Ge,Wenzhang Qi,Yue Xi,Jiayi Wu,Yuxiang Ji,Kexin Chen,Xingjian Lin,Jiu Chen
标识
DOI:10.1021/acschemneuro.1c00595
摘要
The incidence and prevalence of anosognosia are highly variable in amnestic mild cognitive impairment (aMCI) patients. The study aims to explore the neuropathological mechanism of anosognosia in aMCI patients using two different but complementary technologies, including 18F-flortaucipir positron emission tomography and resting state functional magnetic resonance imaging. The study found that anosognosia was related to higher tau accumulation in the left medial orbitofrontal cortex (OFC), left posterior cingulate cortex, and right precuneus in aMCI patients. Intrinsic functional connectivity analyses found significant correlations between anosognosia index and hypoconnectivity between the left medial OFC and left middle temporal gyrus (MTG), right precuneus and left lingual gyrus. Longitudinally, the connectivity of these brain regions as well as the right precuneus and right cuneus showed hyperconnectivity in aMCI patients with anosognosia. The anosognosia index was also correlated with AD pathological markers (i.e., Aβ, t-tau, and p-tau) and brain glucose metabolism in aMCI patients. In conclusion, anosognosia in aMCI patients is associated with the dysfunction of medial OFC-MTG circuit and the precuneus-visual cortex circuit and accelerates clinical progression to AD dementia.
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