医学
弗雷明翰风险评分
内科学
人口
骨矿物
优势比
四分位数
全国健康与营养检查调查
冠状动脉疾病
置信区间
心脏病学
骨质疏松症
疾病
环境卫生
作者
Hyung Tak Lee,Jinho Shin,Seung Yeon Min,Young‐Hyo Lim,Kyung Soo Kim,Soon Gil Kim,Jeong Hyun Kim,Heon Kil Lim
出处
期刊:Coronary Artery Disease
[Ovid Technologies (Wolters Kluwer)]
日期:2015-01-01
卷期号:26 (1): 66-71
被引量:16
标识
DOI:10.1097/mca.0000000000000165
摘要
Introduction Bone mineral density (BMD) is associated with atherosclerosis and vascular calcification. If BMD is related independently to the risk of coronary heart disease (CHD), BMD could play an important role in CHD risk prediction. We assessed the hypothesis that BMD is related independently to the risk of CHD. Materials and methods We used data from the fourth and fifth Korea National Health and Nutrition Examination Surveys. The study sample included men and women aged 20–79 years, who did not have myocardial infarction, angina pectoris, stroke, or diabetes mellitus. We evaluated the relationship between BMD and the Framingham risk score for each sex. Results In the male population, femur neck BMD [coefficient=−2.167, 95% confidence interval (CI) −3.385 to −0.950, P=0.001] and lumbar spine BMD (coefficient=−1.539, 95% CI −2.546 to −0.532, P=0.003) showed an inverse correlation with the Framingham risk score after adjusting for covariates. In the female population, the relationship between BMD parameters and the Framingham risk score was not significant after adjusting for covariates. In the male population, those with femur neck BMD values in the first quartile had greater odds of a 10-year risk greater than or equal to 10% for CHD compared with those in the fourth quartile (odds ratio=1.942, 95% CI 1.315–2.869, P<0.001). Conclusion BMD was correlated inversely with the 10-year risk for CHD in the healthy male population. This result suggests that in the male population, measurement of BMD could be useful for prediction of the risk of CHD.
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