A large-scalable wet-chemical approach to create networked Pt-Pb nanowires (NWs) with tunable compositions is reported. Due to their 3D networked structure, alloy effect, rich defects/steps, and antipoisoning property of Pb, the networked Pt-Pb NWs exhibit the best activity and durability towards ethylene glycol oxidation reaction (EGOR), compared with the networked Pt NWs and Pt/C. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.