On-Set of Cataract and Accumulation of Copper, Lead and Cadmium in Smokers of Karachi, Pakistan

[34][35][36]. Small heat shock proteins are important chaperones found in human lens especially alpha -B crystalline and alpha-A crystallines.Chaperones help in folding of long chains of amino acids and thus prevent aggregation of protein [37], Both crystalline are important for lens transparency [38,39] and survival of lens [40].The C-terminal extension of Alpha B crystalline is responsible for recognizing & selecting of unfolded protein substrate.Removal of C-terminal extension in Alpha B crystalline reduces the chaperone