Relationship Between Electroendosmosis and Plaque Production in Different Agars

A comparison of the electroendosmosis exhibited by an agar and its ability to allow a CBO virus to form plaques in chick embryo fibroblasts shows that these parameters are correlated, indicating that the inhibitor is a negatively charged material, agreeing with the conclusion that it is sulfated polysaccharide. The degree of electroendosmosis may be used as a measure of the suitability of an agar for use in plaque production. Some of the inhibitor appears to be neutralized by fowl serum in the particular virus/cell/agar system used.