细胞器
电子断层摄影术
生物
低温电子层析成像
分辨率(逻辑)
细胞生物学
细胞
断层摄影术
生物物理学
计算生物学
电子显微镜
计算机科学
物理
人工智能
生物化学
光学
扫描透射电子显微镜
作者
Richard McIntosh,Daniela Nicastro,David N. Mastronarde
标识
DOI:10.1016/j.tcb.2004.11.009
摘要
The most important goal of structural cell biology is to elucidate the mechanisms of the processes of life. The structure of a membrane system or fibrous array, the changes in such structures over time or the localizations of enzymes relative to organelle boundaries can often illuminate associated cellular functions. To be of maximal value, structural studies should provide isotropic, 3D information about well-preserved samples at the highest possible resolution. Electron tomography can provide such information about many kinds of cells and organelles. The most important goal of structural cell biology is to elucidate the mechanisms of the processes of life. The structure of a membrane system or fibrous array, the changes in such structures over time or the localizations of enzymes relative to organelle boundaries can often illuminate associated cellular functions. To be of maximal value, structural studies should provide isotropic, 3D information about well-preserved samples at the highest possible resolution. Electron tomography can provide such information about many kinds of cells and organelles.
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