LMNA公司
医学
拉明
扩张型心肌病
埃默林
突变
猝死
心源性猝死
心脏病学
心肌病
基因突变
内科学
疾病
遗传学
基因
心力衰竭
核蛋白
核心
精神科
生物
转录因子
作者
Stéphanie Brette,I. Pénisson-Besnier,Dupuis Jm,Gisèle Bonne,J Victor
出处
期刊:PubMed
日期:2004-10-01
卷期号:97 (10): 973-7
被引量:1
摘要
Dilated cardiomyopathy (DCM) of genetic origin represents about 25% of all so-called primary DCM. Cases due to mutation of the gene which codes the lamins A and C (LMNA) carry a poor prognosis with a high risk of sudden death. The finding of primary DCM in a young person associated with conduction defects or arrhythmias should lead to investigation for mutation of the gene of lamins A and C, even in the absence of a suggestive family history. The authors report 5 cases of DCM, with and without associated skeletal muscular disease, due to laminopathies.
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