亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Effects of Sleep Deprivation on Mice Bone Marrow and Spleen B Lymphopoiesis

脾脏 淋巴细胞生成 骨髓 免疫系统 内分泌学 B细胞 淋巴细胞 氧化应激 内科学 祖细胞 睡眠剥夺 造血 生物 免疫学 干细胞 医学 抗体 昼夜节律 细胞生物学
作者
Lisandro Lungato,Amanda Nogueira-Pedro,Carolina Dias,Edgar Julian Paredes-Gamero,Sergio Tufik,Vânia D'Almeida
出处
期刊:Journal of Cellular Physiology [Wiley]
被引量:5
标识
DOI:10.1002/jcp.25231
摘要

B lymphocytes are immune cells crucial for the maintenance and viability of the humoral response. Sleep is an essential event for the maintenance and integrity of all systems, including the immune system (IS). Thus, sleep deprivation (SD) causes problems in metabolism and homeostasis in many cell systems, including the IS. In this study, our goal was to determine changes in B lymphocytes from the bone marrow (BM) and spleen after SD. Three-month-old male Swiss mice were used. These mice were sleep deprived through the modified multiple platform method for different periods (24, 48, and 72 h), whereas another group was allowed to sleep for 24 h after 72 h of SD (rebound group) and a third group was allowed to sleep normally during the entire experiment. After this, the spleen and BM were collected, and cell analyses were performed. The numbers of B lymphocytes in the BM and spleen were reduced by SD. Additionally, reductions in the percentage of lymphocyte progenitors and their ability to form colonies were observed. Moreover, an increase in the death of B lymphocytes from the BM and spleen was associated with an increase in oxidative stress indicators, such as DCFH-DA, CAT, and mitochondrial SOD. Rebound was not able to reverse most of the alterations elicited by SD. The reduction in B lymphocytes and their progenitors by cell death, with a concomitant increase in oxidative stress, showed that SD promoted a failure in B lymphopoiesis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
15秒前
27秒前
42秒前
1分钟前
肆肆完成签到,获得积分10
1分钟前
2分钟前
锋feng完成签到 ,获得积分10
2分钟前
你博哥完成签到 ,获得积分10
3分钟前
4分钟前
陶沛发布了新的文献求助10
5分钟前
大喵完成签到,获得积分10
6分钟前
爱静静完成签到,获得积分0
6分钟前
Jenny完成签到 ,获得积分10
7分钟前
书文混四方完成签到 ,获得积分10
8分钟前
8分钟前
隐形问萍完成签到,获得积分10
8分钟前
隐形问萍发布了新的文献求助10
9分钟前
FSYHantis完成签到,获得积分10
10分钟前
陈元元K完成签到,获得积分10
11分钟前
wangye完成签到 ,获得积分10
11分钟前
名侦探柯基完成签到 ,获得积分10
12分钟前
Jack80应助科研通管家采纳,获得50
12分钟前
cy0824完成签到 ,获得积分10
12分钟前
个性松完成签到 ,获得积分10
13分钟前
TAOTAO完成签到 ,获得积分10
13分钟前
14分钟前
麻将发布了新的文献求助10
14分钟前
16分钟前
活泼蜜蜂应助程风破浪采纳,获得10
16分钟前
毕个业完成签到 ,获得积分10
16分钟前
16分钟前
mengyuhuan完成签到 ,获得积分10
17分钟前
光亮的城完成签到 ,获得积分10
17分钟前
科研通AI2S应助wobuxin采纳,获得10
18分钟前
领导范儿应助CHEN采纳,获得10
19分钟前
20分钟前
CHEN发布了新的文献求助10
20分钟前
CHEN完成签到,获得积分10
20分钟前
星辰大海应助Bo采纳,获得10
20分钟前
21分钟前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3162343
求助须知:如何正确求助?哪些是违规求助? 2813330
关于积分的说明 7899719
捐赠科研通 2472848
什么是DOI,文献DOI怎么找? 1316533
科研通“疑难数据库(出版商)”最低求助积分说明 631375
版权声明 602142