选择(遗传算法)
遗产管理(遗嘱认证法)
医学
风险分析(工程)
计算机科学
政治学
人工智能
法学
作者
Patricia V. Turner,Cynthia Pekow,Mary Ann Vasbinder,Thea Brabb
出处
期刊:PubMed
日期:2011-09-01
卷期号:50 (5): 614-27
被引量:126
摘要
Administration of substances to laboratory animals requires careful consideration and planning to optimize delivery of the agent to the animal while minimizing potential adverse experiences from the procedure. The equipment selected to deliver substances to animals depends on the length of the study and the nature of the material being administered. This selection provides a significant opportunity for refining animal treatment. Similarly, when substances are administered as solutions or suspensions, attention should be given to selection of vehicles and methods used for preparing the solutions and suspensions. The research team, veterinarian, technical personnel, and IACUC members should be aware of reasons underlying selection of equipment for substance delivery and should consider carefully how substances will be prepared and stored prior to administration to animals. Failure to consider these factors during experimental planning may result in unintentional adverse effects on experimental animals and confounded results.
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