病毒学
免疫原性
猫传染性腹膜炎
重组DNA
生物
中和抗体
抗体
效价
冠状病毒
穗蛋白
重组病毒
病毒
基因
医学
免疫学
传染病(医学专业)
2019年冠状病毒病(COVID-19)
遗传学
疾病
病理
作者
Harry Vennema,Raoul J. de Groot,D. A. Harbour,Mieke J.M. Dalderup,Tim Gruffydd-Jones,Marian C. Horzinek,Willy J. M. Spaan
标识
DOI:10.1007/978-1-4684-5823-7_30
摘要
The gene encoding the fusogenic spike protein of the coronavirus causing feline infectious peritonitis (FIPV) was recombined into the genome of vaccinia virus, strain WR. The recombinant induced spike protein specific, in vitro neutralizing antibodies in mice. When kittens were immunized with the recombinant, low titers of neutralizing antibodies were obtained. After challenge with FIPV, these animals succumbed earlier than the vWR-immunized control group ("early death syndrome").
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