时间1
癌症
癌变
基质金属蛋白酶
间质细胞
细胞生物学
基因沉默
癌症研究
基质
蛋白酵素
癌细胞
细胞外基质
生物
医学
病理
免疫学
酶
基因表达
免疫组织化学
基因
生物化学
遗传学
作者
Hartland W. Jackson,Virginie Defamie,Paul Waterhouse,Rama Khokha
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2016-12-09
卷期号:17 (1): 38-53
被引量:361
摘要
A compelling long-term goal of cancer biology is to understand the crucial players during tumorigenesis in order to develop new interventions. Here, we review how the four non-redundant tissue inhibitors of metalloproteinases (TIMPs) regulate the pericellular proteolysis of a vast range of matrix and cell surface proteins, generating simultaneous effects on tumour architecture and cell signalling. Experimental studies demonstrate the contribution of TIMPs to the majority of cancer hallmarks, and human cancers invariably show TIMP deregulation in the tumour or stroma. Of the four TIMPs, TIMP1 overexpression or TIMP3 silencing is consistently associated with cancer progression or poor patient prognosis. Future efforts will align mouse model systems with changes in TIMPs in patients, will delineate protease-independent TIMP function, will pinpoint therapeutic targets within the TIMP-metalloproteinase-substrate network and will use TIMPs in liquid biopsy samples as biomarkers for cancer prognosis.
科研通智能强力驱动
Strongly Powered by AbleSci AI