遗传力
多基因风险评分
疾病
医学
生物
内科学
遗传学
基因型
单核苷酸多态性
基因
作者
Valentina Escott‐Price,Maryam Shoai,Richard Pither,Julie Williams,John Hardy
标识
DOI:10.1016/j.neurobiolaging.2016.07.018
摘要
We estimate the maximum prediction accuracy for the risk of Alzheimer's disease based on disease prevalence and heritability of liability. We demonstrate that the recently reported AUC values for predicting of Alzheimer's disease using polygenic scores reach about 90% of the estimated maximum accuracy that can be achieved by predictors of genetic risk based on genomic profiles.
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