A Unified Synthetic Approach to Optically Pure Curvularin-Type Metabolites

A unified and concise approach to the synthesis of nine curvularin-type metabolites and two analogues has been developed with few steps and high yields. Among them, sumalactones A–D were synthesized for the first time. The key steps in this approach included esterification, Friedel–Crafts acylation, and ring-closing metathesis (or cross metathesis).