Drug Release and Mucoadhesive behavior of Hydrogel in Chemo-Radiotherapy induced Oral Mucositis

In vitro drug release investigations are obligatory tool in the drug product development. Mucoadhesion time and viscosity are vitals in adherence with comprehensive period of time. Oral mucositis is a frequent and potentially severe obstacles caused by chemo-radiotherapy. L-Glutamine reported to reduce the length and severity of chemo-radiotherapy induced oral mucositis. Hydrogel is biocompatible, resilient, and mucoadhesive in local delivery of active ingredient in buccal cavity. The aim of the present study was to evaluate in vitro drug release, mucoadhesion of L-Glutamine hydrogels. Hydrogels of L-Glutamine containing natural and synthetic bioadhesive polymers (w/w %): Carbopol 934P (0.25–1), Guar gum (0.05–1), Gum acacia (0.15–1) and Sodium Alginate (0.1–1) were prepared along with other adjutants. These hydrogel were evaluated for different physicochemical attributes (pH, viscosity, drug release, mucoadhesion). The prepared hydrogel were homogenous and opaque with suitable pH (6–7). The formulation containing 0.5% Carbopol 934P (CG2) showed the highest release rate (>85%), order of release rate was Guar gum > Gum acacia > Sodium alginate. Mucoadhesion (>6 hours, CG3