Effect of intravenous diclofenac on pain and recovery profile after day-case laparoscopy.

医学 芬太尼 麻醉 腹腔镜检查 恶心 双氯芬酸 止痛药 输卵管结扎术 异丙酚 双氯芬酸钠 生理盐水 呕吐 外科 人口 计划生育 环境卫生 药理学 研究方法
作者
J. Hovorka,Heidi Kallela,Kari Korttila
出处
期刊:PubMed 卷期号:10 (2): 105-8 被引量:32
链接
标识
摘要

Diclofenac sodium, 100 mg, or saline was given intravenously after the induction of anaesthesia to 169 patients undergoing outpatient gynaecological diagnostic laparoscopy or laparoscopic sterilization by tubal ligation. Propofol was used as the main anaesthetic agent and fentanyl and paracetamol were given for post-operative pain relief. In the post-anaesthesia care unit the amount of analgesics given and the incidence of nausea and vomiting were recorded. The time until oral intake, voiding and walking without assistance were recorded as parameters of recovery and guidelines for discharging the patient. In the diagnostic laparoscopy group, the patients given diclofenac needed significantly (P < 0.05) less fentanyl (25 +/- 33 micrograms, mean +/- SD) and paracetamol (230 +/- 40 mg) for post-operative pain than the patients given saline (fentanyl 47 +/- 53 micrograms and paracetamol 690 +/- 100 mg), which was not the case in the tubal ligation group. However, patients in the tubal ligation group needed significantly more post-operative analgesia than patients in the laparoscopy group. Diclofenac had no influence on the rapidity of recovery or home readiness in either group. It is concluded that diclofenac has no influence on home readiness, but prevents postoperative pain in patients undergoing diagnostic laparoscopies, whereas it was not a potent enough analgesic to prevent pain after laparoscopic tubal ligation.At Helsinki University Central Hospital in Finland, clinical researchers divided 169 women into two groups (group 1: diagnostic laparoscopies; group 2: laparoscopic sterilizations) as part of a study to evaluate the effect of intravenous diclofenac on postoperative pain, nausea, and recovery after outpatient gynecological laparoscopy. After induction of anesthesia (propofol infusion, total dose = about 370 mg), the patients randomly received, in a double-blind approach, either 100 mg diclofenac sodium (Voltaren, Ciba-Geigy) diluted in 10 ml saline or 10 ml saline alone. Patients in the saline group needed much more fentanyl and paracetamol for pain relief than those in the diclofenac group (47 vs. 25 mcg and 0.69 vs. 0.23 g, respectively; p 0.05). Even though a higher proportion of diclofenac patients experienced postoperative nausea and vomiting (17% vs. 6%) and thus were more likely to receive droperidol (9% vs. 2%), the differences were not statistically significant. Laparoscopic sterilization patients experienced more pain and required more pain relievers postoperatively than diagnostic laparoscopy patients. Specifically, sterilization patients receiving saline received 2.8 times more fentanyl and 1.9 times more paracetamol than diagnostic laparoscopy patients. As for diclofenac patients, these figures were 4.9 and 5.5, respectively. Sterilization patients had more nausea and vomiting than diagnostic laparoscopy patients (34% vs. 11%; p 0.001). Diclofenac did not influence the rapidity of recovery or home readiness in either group. These findings show that diclofenac significantly reduced the need for postoperative analgesia in diagnostic laparoscopy patients but not laparoscopic sterilization patients.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
遇见完成签到 ,获得积分10
1秒前
JinwenShi完成签到,获得积分10
3秒前
HXuer完成签到,获得积分10
4秒前
6秒前
kyJYbs发布了新的文献求助20
7秒前
9秒前
Ava应助WW采纳,获得30
9秒前
song完成签到 ,获得积分10
11秒前
11秒前
Tei发布了新的文献求助30
11秒前
12秒前
hahhhhhh2发布了新的文献求助10
13秒前
邱夫斯基发布了新的文献求助10
17秒前
尊敬的半梅完成签到 ,获得积分10
17秒前
18秒前
完美世界应助苗条的大树采纳,获得10
18秒前
18秒前
坛子发布了新的文献求助10
19秒前
19秒前
19秒前
20秒前
大模型应助这个郭我背了采纳,获得10
21秒前
科研通AI2S应助科研小白采纳,获得10
22秒前
大刘完成签到 ,获得积分10
23秒前
23秒前
堀江真夏发布了新的文献求助10
23秒前
24秒前
25秒前
WWXWWX发布了新的文献求助10
25秒前
26秒前
26秒前
思源应助WWXWWX采纳,获得10
29秒前
30秒前
科研通AI2S应助攻心采纳,获得10
32秒前
汤汤发布了新的文献求助10
32秒前
32秒前
32秒前
热心小小发布了新的文献求助10
32秒前
斯文败类应助Windycityguy采纳,获得10
33秒前
33秒前
高分求助中
Earth System Geophysics 1000
Studies on the inheritance of some characters in rice Oryza sativa L 600
Medicina di laboratorio. Logica e patologia clinica 600
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
Language injustice and social equity in EMI policies in China 500
mTOR signalling in RPGR-associated Retinitis Pigmentosa 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3206752
求助须知:如何正确求助?哪些是违规求助? 2856202
关于积分的说明 8103078
捐赠科研通 2521321
什么是DOI,文献DOI怎么找? 1354373
科研通“疑难数据库(出版商)”最低求助积分说明 642012
邀请新用户注册赠送积分活动 613209