A Small CEACAM5 Peptide Restores the Protective Function of CD8+ Regulatory T Cells in Crohn’s Disease

See editorial on page 822. A CEACAM5-derived Peptide Activating CD8+ Regulatory T Cells: A Future Option for Restoring Mucosal Homeostasis in Crohn’s Disease?GastroenterologyVol. 163Issue 4PreviewRegulatory T cells are key players in the maintenance of intestinal homeostasis. A defect or a lack of activation of regulatory T cells can lead to mucosal inflammation. Many subsets of T cells with a regulatory function are present in the intestinal mucosa.1 Yio and Mayer2 explored during his career the role of intestinal epithelial cells (IEC) in regulating mucosal immune responses. He and his group identified a molecule expressed on normal IEC that appears to play a role in the activation of antigen nonspecific CD8+ suppressor T cells. Full-Text PDF