Trials, tribunals, and opportunities for lung cancer KRASG12C brain metastases

Abstract The activity of KRAS inhibitors against brain metastases is relatively unexplored. The recent work on pre-clinical models and preliminary data from the ongoing KRYSTAL-1 phase 1b clinical trial support the potential of adagrasib (MRTX849) to penetrate the central nervous system (CNS) and provide control of KRASG12C brain metastases.