体内
炎症
体外
药理学
NF-κB
p38丝裂原活化蛋白激酶
化学
MAPK/ERK通路
肿瘤坏死因子α
细胞生物学
生物化学
生物
信号转导
免疫学
生物技术
作者
Binjie Lu,Xiaolei Chen,Hua Chen,Qian Li,Hongwei Li,Yue Xu,Yuwei Li,Xiaofeng Shen,Rilei Jiang
标识
DOI:10.1016/j.intimp.2022.108914
摘要
The inflammatory radicular pain induced by lumbar disc herniation (LDH) is a serious problem worldwide. Demethoxycurcumin (DMC) is a yellow pigment derived from turmeric. Although it is considered a safe natural compound for managing inflammation-associated diseases, but the molecular mechanisms of LDH remain to be elucidated. In the current study, DMC reduced the production of IL-1β, IL-4, and IL-6 in nucleus pulposus (NP) cells subjected to TNF-α-induced inflammation. Moreover, the inhibitory mechanism was activated upon suppression of activation of MAPKs and NF-κB signalling in NP cells. Further experiments with LDH model rats supported the in vitro results. These studies expand our knowledge of the effect of DMC on LDH; DMC may be a viable alternative to the drugs used to treat LDH.
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