医学
生殖细胞肿瘤
腰骶关节
蹒跚学步的孩子
化疗
生殖细胞瘤
病理
放射治疗
中枢神经系统
外科
内科学
心理学
发展心理学
作者
Subramaniam Ramanathan,Rebecca J. Hill,Jade Ryles,Gail C. Halliday,Dipayan Mitra,Simon Bailey
出处
期刊:Journal of Pediatric Hematology Oncology
[Ovid Technologies (Wolters Kluwer)]
日期:2022-05-23
卷期号:45 (3): e415-e418
标识
DOI:10.1097/mph.0000000000002486
摘要
Central nervous system germ cell tumors (CNS-GCTs) comprise 4% of all pediatric CNS tumors, with one third being nongerminomatous GCT (CNS-NG-GCT) type. The majority of these tumors arise in the intracranial compartment with 20% having drop metastases in the spine. We present a rare case of a 2-year-old boy with a primary intradural-extramedullary NG-GCT arising from the lumbosacral spine with a trifecta of unfavorable features, that is, young age, alpha-feto protein >1000 ng/mL, and disseminated disease within the cranium. Owing to his young age, he was treated with chemotherapy alone, avoiding radiation. His tumor marker (alpha-feto protein) declined from 8468 to 10 k-U/L over 8 weeks, and he remained in remission at the last follow-up. This atypical presentation of an intradural-extramedullary tumor with cranial dissemination in a childhood NG-GCT has yet to be described in the literature. Here we use this opportunity to highlight the treatment strategies and challenges in this unique clinical case.
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