Non-typhoidal salmonella invasive infections in China

病死率 医学 斯科普斯 沙门氏菌 中国大陆 中国 人口 死亡率 内科学 人口学 流行病学 梅德林 环境卫生 地理 政治学 生物 考古 社会学 法学 细菌 遗传学
作者
Yanyan Hu,Jian Wang,Shi Chen,Yi Li,Rong Zhang,Sheng Chen
出处
期刊:Lancet Infectious Diseases [Elsevier BV]
卷期号:22 (7): 939-939 被引量:11
标识
DOI:10.1016/s1473-3099(22)00347-4
摘要

We read with interest the Article by Christian S Marchello and colleagues.1Marchello CS Birkhold M Crump JA Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis.Lancet Infect Dis. 2022; 22: 692-705Summary Full Text Full Text PDF PubMed Scopus (4) Google Scholar The study reported that the most prevalent complications of invasive salmonella infection were septicaemia (171 [57·2%] of 299 participants) and anaemia (580 [47·3%] of 1225 participants), with a case fatality rate of 14·7% (95% CI 12·2–17·3). The pooled case fatality rate varied between different continents: 17·1% (13·6–21·0) in Africa, 14·0% (9·4–19·4) in Asia, 9·9% (6·4–14·0) in Europe, and 9·6% (0·0–25·1) in the Americas. However, data from Asia did not include the case fatality rates in mainland China. To address the absence of data from mainland China in the study,1Marchello CS Birkhold M Crump JA Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis.Lancet Infect Dis. 2022; 22: 692-705Summary Full Text Full Text PDF PubMed Scopus (4) Google Scholar we analysed clinical data on salmonella infections collected from 56 tertiary hospitals and 131 secondary hospitals in Henan province, and data from 90 tertiary hospitals and 47 secondary hospitals in Zhejiang province over 3 years from 2018 to 2020. The hospitals included in our analysis serve a population of 65 million people in Henan and 45 million people in Zhejiang. Our data showed that salmonella infections in children (<15 years of age, accounting for 1181 [61·8%] of 1910 cases of infection in Henan and 3224 [52·8%] of 6111 in Zhejiang) were more common than in adult patients. In tertiary hospitals, the overall rate of isolation of Salmonella spp among all bacterial pathogens was 0·64% (1401 of 218 906 isolates) in Henan and 0·55% (4868 of 885 090 isolates) in Zhejiang, which was higher than the isolation rate in secondary hospitals (509 [0·33%] of 154 242 isolates in Henan and 1243 [0·49%] of 253 673 isolates in Zhejiang). 833 (43·6%) of 1910 patients in Henan and 1280 (20·9%) of 6111 patients in Zhejiang had invasive salmonella infections. 566 (67·9%) of 833 people with invasive salmonella infections in Henan and 676 (52·8%) of 1280 people with invasive salmonella infections in Zhejiang had bloodstream infection. For 73 (8·8%) of 833 cases of invasive infection in Henan and 211 (16·5%) of 1280 cases of invasive infection in Zhejiang, Salmonella spp were isolated from different types of drained fluid. 36 (4·3%) of 833 cases in Henan and 107 (8·4%) of 1280 cases in Zhejiang were salmonella-mediated urinary tract infections (appendix pp 1–2). The data on bloodstream infections are consistent with the report of Marchello and colleagues,1Marchello CS Birkhold M Crump JA Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis.Lancet Infect Dis. 2022; 22: 692-705Summary Full Text Full Text PDF PubMed Scopus (4) Google Scholar which showed that septicaemia occurred in 171 (57·2%) of 299 participants with invasive infection. Of note, anaemia was not analysed in our study. The most intriguing finding in our study was that none of the cases of invasive infection were fatal—an observation that is in stark contrast with most studies reported in various countries.1Marchello CS Birkhold M Crump JA Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis.Lancet Infect Dis. 2022; 22: 692-705Summary Full Text Full Text PDF PubMed Scopus (4) Google Scholar Nevertheless, zero mortality was reported in several countries and regions, such as Taiwan, Vietnam, Malaysia, Israel, and Turkey.1Marchello CS Birkhold M Crump JA Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysis.Lancet Infect Dis. 2022; 22: 692-705Summary Full Text Full Text PDF PubMed Scopus (4) Google Scholar In conclusion, our data provide more insight into the clinical outcome of invasive salmonella infections and suggest that mortality rates vary widely between different regions and countries, which needs to be investigated. We declare no competing interests. The research reported here was funded by Guangdong Major Project of Basic and Applied Basic Research (2020B0301030005). Editorial note: The Lancet Group takes a neutral position with respect to territorial claims in published text and institutional affiliations. Download .pdf (.23 MB) Help with pdf files Supplementary appendix Complications and mortality of non-typhoidal salmonella invasive disease: a global systematic review and meta-analysisComplications were frequent among individuals with non-typhoidal salmonella invasive disease and approximately 15% of patients died. Clinicians, especially in African countries, should be aware of non-typhoidal salmonella invasive disease as a cause of severe febrile illness. Prompt diagnoses and management decisions, including empiric antimicrobial therapy, would improve patient outcomes. Additionally, investments in improving clinical microbiology facilities to identify non-typhoidal salmonella and research efforts towards vaccine development and non-vaccine prevention measures would prevent non-typhoidal salmonella invasive disease-associated illness and death. Full-Text PDF Open Access
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
上官若男应助俏皮的白柏采纳,获得10
刚刚
量子星尘发布了新的文献求助10
3秒前
充电宝应助Jay采纳,获得10
5秒前
orixero应助qp采纳,获得10
7秒前
醍醐不醒完成签到 ,获得积分10
8秒前
gaberella完成签到,获得积分10
9秒前
沐晴发布了新的文献求助150
10秒前
LANER完成签到 ,获得积分10
10秒前
11秒前
xmk完成签到 ,获得积分10
12秒前
cindywu完成签到,获得积分10
12秒前
ccc发布了新的文献求助10
12秒前
14秒前
15秒前
16秒前
16秒前
Star1983发布了新的文献求助10
20秒前
20秒前
坚定馒头发布了新的文献求助10
20秒前
项绝义发布了新的文献求助200
21秒前
Supreme发布了新的文献求助10
23秒前
24秒前
24秒前
26秒前
26秒前
26秒前
28秒前
青柠发布了新的文献求助10
28秒前
nannan发布了新的文献求助10
29秒前
30秒前
30秒前
30秒前
TKTK发布了新的文献求助30
30秒前
Stroeve发布了新的文献求助20
31秒前
35秒前
36秒前
37秒前
39秒前
lelelele发布了新的文献求助10
39秒前
40秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988920
求助须知:如何正确求助?哪些是违规求助? 3531290
关于积分的说明 11253247
捐赠科研通 3269903
什么是DOI,文献DOI怎么找? 1804830
邀请新用户注册赠送积分活动 882027
科研通“疑难数据库(出版商)”最低求助积分说明 809052