Biological ageing and the risks of all-cause and cause-specific mortality among people with diabetes: a prospective cohort study

医学 老化 糖尿病 比例危险模型 危险系数 内科学 人口 队列 疾病 前瞻性队列研究 队列研究 死因 生物年龄 2型糖尿病 病因学 老年学 人口学 内分泌学 环境卫生 置信区间 社会学
作者
Li Chen,Xingzhu Yin,Ying Zhao,Huimin Chen,Tianqi Tan,Ping Yao,Yuhan Tang
出处
期刊:Journal of Epidemiology and Community Health [BMJ]
卷期号:76 (9): 771-778 被引量:40
标识
DOI:10.1136/jech-2022-219142
摘要

Background The aetiology of diabetes is complex with limited treatment strategies. Growing animal studies have shown that targeted antiageing can improve the outcomes of diabetes. However, population evidence is limited. This study aims to evaluate the associations of biological ageing with all-cause and cause-specific mortality among people with diabetes. Methods A total of 5278 people with diabetes from the National Health and Nutrition Examination Survey 1999–2014 were included. Biological ageing was measured from different perspectives, including phenotypic age, biological age, telomere length and klotho concentration. Phenotypic/biological age acceleration was the residual resulting from a linear model when regressing phenotypic/biological age on chronological age. Cox proportional hazards models were used to examine the relationships between ageing and all-cause, cardiovascular disease (CVD), and cancer mortality. Results Over median follow-up for 7.3 years, 1355 diabetics died. There was a positive and linear association of mortality with phenotypic age acceleration (HR all-cause 1.04; HR CVD 1.04; HR cancer 1.04, p<0.001) and biological age acceleration (HR all-cause 1.03; HR CVD 1.04; HR cancer 1.03, p<0.001). Telomere length was inversely associated with all-cause mortality (tertile (T)3 vs T1: HR 0.67, p<0.05). The concentration of klotho had a U-shaped relationship with mortality (T2 vs T1: HR all-cause 0.62; HR CVD 0.48; HR cancer 0.47, p<0.05). Further, stratified analysis by age and sex found that the associations of ageing-related markers with mortality were more significant in the aged and female subgroup. Conclusions Biological ageing was positively associated with mortality among people with diabetes, indicating therapies targeting antiageing could be encouraged to halt the progression of diabetes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
koutianle完成签到 ,获得积分10
1秒前
yan完成签到,获得积分10
2秒前
非对称转录完成签到,获得积分0
2秒前
SYSUer发布了新的文献求助10
2秒前
2秒前
plumcute完成签到,获得积分10
3秒前
wure10完成签到 ,获得积分10
3秒前
生活不是电影完成签到,获得积分10
4秒前
想人陪的飞薇完成签到 ,获得积分10
5秒前
七七发布了新的文献求助10
7秒前
爱听歌凤灵完成签到,获得积分10
8秒前
8秒前
所所应助坚强的安柏采纳,获得10
8秒前
panfan完成签到,获得积分10
8秒前
8秒前
Abi完成签到,获得积分10
9秒前
DijiaXu完成签到,获得积分10
9秒前
清脆的靖仇应助1111采纳,获得10
10秒前
忐忑的邑完成签到,获得积分10
10秒前
鳄鱼蛋完成签到,获得积分10
10秒前
ENG完成签到,获得积分10
11秒前
仝富贵完成签到,获得积分10
12秒前
12秒前
认真的灵竹完成签到 ,获得积分10
12秒前
dahuihui发布了新的文献求助10
13秒前
xx完成签到,获得积分10
13秒前
犹豫的天问完成签到,获得积分10
13秒前
木木三发布了新的文献求助10
13秒前
14秒前
lzl008完成签到 ,获得积分10
14秒前
飞飞完成签到,获得积分10
14秒前
积极松鼠完成签到,获得积分10
15秒前
入暖完成签到,获得积分10
16秒前
16秒前
one完成签到 ,获得积分10
16秒前
完美的友蕊应助孟孟采纳,获得10
16秒前
沉静冬易完成签到,获得积分10
16秒前
个性的翠芙完成签到 ,获得积分10
16秒前
whitebird完成签到,获得积分10
17秒前
羊驼完成签到,获得积分10
17秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968593
求助须知:如何正确求助?哪些是违规求助? 3513416
关于积分的说明 11167791
捐赠科研通 3248853
什么是DOI,文献DOI怎么找? 1794507
邀请新用户注册赠送积分活动 875170
科研通“疑难数据库(出版商)”最低求助积分说明 804671