犬尿氨酸
犬尿氨酸途径
吲哚胺2,3-双加氧酶
氧化应激
胶质瘤
生物
氧化磷酸化
分解代谢
色氨酸代谢
下调和上调
癌症研究
化学
细胞生物学
色氨酸
生物化学
酶
基因
氨基酸
作者
Marta Obara‐Michlewska
标识
DOI:10.1016/j.neuint.2022.105363
摘要
The kynurenine pathway receives increasing attention due to its involvement in central nervous system pathologies, i.a. neurodegenerative and psychiatric disorders, but also due to the contribution to the pathomechanism of neoplasms, including brain tumors. The present review focuses on kynurenine pathway activity in gliomas, brain tumors of glial origin. The upregulation of kynurenine pathway enzyme, indoleamine 2,3-dioxygenase (IDO), resulting in a decreased level of tryptophan and augmented kynurenine synthesis (increased (KYN/Trp ratio) are the most recognised hallmark of malignant transformation, characterised with immunomodulatory adaptations, providing an escape from defence mechanisms of the host, growth-beneficial milieu and resistance to some therapeutics. The review addresses, however, the oxidative/nitrosative stress-associated mechanisms of tryptophan catabolism, mainly the kynurenine pathway activity, linking them with glioma pathobiology.
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