电休克疗法
重性抑郁障碍
默认模式网络
萧条(经济学)
功能磁共振成像
静息状态功能磁共振成像
心理学
神经科学
拓扑(电路)
精神科
医学
认知
数学
组合数学
经济
宏观经济学
作者
Yuanyuan Li,Yue Li,Qiang Wei,Tongjian Bai,Kai Wang,Jiaojian Wang,Yanghua Tian
标识
DOI:10.1016/j.jad.2022.05.067
摘要
Disrupted topological organization of functional brain networks has been well documented in major depressive disorder (MDD). However, there is no report about how electroconvulsive therapy (ECT), a rapid way for depression remission, affects whole-brain functional network topological architecture to improve clinical symptoms in individuals with MDD. In this study, resting-state functional magnetic resonance imaging (rs-fMRI) data were collected for twenty-four MDD patients before and after receiving ECT and 25 gender-, age- and education-matched healthy controls (HC). The functional brain network for each subject was mapped using Brainnetome Atlas and graph-theory was applied to measure topological properties for both binary and weighted network. The results showed that ECT can significantly increase shortest path length and decrease global efficiency in MDD patients. In addition, significant alterations in nodal degree, nodal efficiency as well as between nodal functional connectivity strength were found in MDD patients after ECT. The network nodes showing changed degree, efficiency and connectivity were primarily distributed in default mode network (DMN), fronto-parietal network (FPN), and limbic system. Our findings demonstrates that ECT improves depressive symptoms by reorganizing disrupted network topological architecture in MDD patients and highlights the important role of functional reorganization of DMN, FPN, and limbic network contributing to depression remission.
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