Study on the Mechanism of Coptis Chinensis in Treating Gastric Ulcer Based on Network Pharmacology and Computer Technology

Objective: Investigate the mechanism of Coptis chinensis in the treatment of Gastric Ulcer based on network pharmacology and computer technology. Methods: The chemical constituts were collected based on the TCMSP database by using Coptis chinensis as the key word; GeneCards were used to select the target genes related to Gastric Ulcer from the human gene database, and the Gastric Ulcer's related target genes were screened by Genemap in the OMIM database, Disgenet database and Genecards database. We used R language VennDiagram package to crosse the gene targets of drugs and diseases, and screenthe target of the main components of Coptis chinensis in the treatment of Gastric Ulcer, and to use Cytoscape software to map the gene regulatory network of galangal in the treatment of Gastric Ulcer, and to use the String database to construct the gene-protein of Coptis chinensis. The interaction visualization network map for protein-protein interaction (PPI) were screened out the core genes. On this basis, gene ontology process analysis and Kyoto Encyclopedia of genes and genomes pathway enrichment analysis were performed using Bioconductor database. Results: Fourteen main active compounds of Coptis chinensis were screened, and 138 gene targets may be involved in the treatment of Gastric Ulcer. The main function of Coptis in the treatment of gastric ulcer is to combine various proteins with different functions such as Akt1, EGFR, MAPK3, TNF etc. The results of GO and KEGG pathway analysis indicated that the pathways involved include P13K/Akt, VEGF and TNF signaling pathway and a variety of cancer pathways. Conclusions: Coptis in the treatment of gastric ulcer in the process of the use of multi-channel joint collaborative approach, laid the foundation for further research.