大流行
免疫系统
免疫学
信使核糖核酸
医学
适应性
病毒学
传染病(医学专业)
生物
疾病
2019年冠状病毒病(COVID-19)
遗传学
病理
生态学
基因
作者
Jinjin Chen,Jianzhu Chen,Qiaobing Xu
标识
DOI:10.1146/annurev-bioeng-110220-031722
摘要
mRNA vaccines have brought about a great revolution in the vaccine fields owing to their simplicity and adaptability in antigen design, potential to induce both humoral and cell-mediated immune responses and demonstrated high efficacy, and rapid and low-cost production by using the same manufacturing platform for different mRNA vaccines. Multiple mRNA vaccines have been investigated for both infectious diseases and cancers, showing significant superiority to other types of vaccines. Although great success of mRNA vaccines has been achieved in the control of the coronavirus disease 2019 pandemic, there are still multiple challenges for the future development of mRNA vaccines. In this review, the most recent developments of mRNA vaccines against both infectious diseases and cancers are summarized for an overview of this field. Moreover, the challenges are also discussed on the basis of these developments.
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