肿瘤微环境
过氧化氢
材料科学
光热治疗
化学
上睑下垂
生物化学
纳米技术
癌症研究
生物
细胞凋亡
程序性细胞死亡
肿瘤细胞
作者
Liang Zhang,Qi‐Chao Yang,Shuo Wang,Yao Xiao,Shu‐Cheng Wan,Hexiang Deng,Zhi‐Jun Sun
标识
DOI：10.1002/adma.202108174
摘要
The engineering of a series of multienzyme-mimicking covalent organic frameworks (COFs), COF-909-Cu, COF-909-Fe, and COF-909-Ni, as pyroptosis inducers, remodeling the tumor microenvironment to boost cancer immunotherapy, is reported. Mechanistic studies reveal that these COFs can serve as hydrogen peroxide (H
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