重编程
细菌
生化工程
基因工程
合成生物学
计算生物学
生物
纳米技术
计算机科学
工程类
材料科学
遗传学
细胞
基因
作者
Jin‐Xuan Fan,Mei‐Ting Niu,You‐Teng Qin,Yunxia Sun,Xian‐Zheng Zhang
标识
DOI:10.1016/j.addr.2022.114296
摘要
Recently, with the rapid development of bioengineering technology and nanotechnology, natural bacteria were modified to change their physiological activities and therapeutic functions for improved therapeutic efficiency of diseases. These engineered bacteria were equipped to achieve directed genetic reprogramming, selective functional reorganization and precise spatio-temporal control. In this review, research progress in the basic modification methodologies of engineered bacteria were summarized, and representative researches about their therapeutic performances for tumor treatment were illustrated. Moreover, the strategies for the construction of engineered colonies based on engineering of individual bacteria were summarized, providing innovative ideas for complex functions and efficient anti-tumor treatment. Finally, current limitation and challenges of tumor therapy utilizing engineered bacteria were discussed.
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