Increased anteroventral striatal dopamine transporter and motor recovery after subthalamic deep brain stimulation in Parkinson’s disease

壳核 多巴胺转运体 脑深部刺激 丘脑底核 伏隔核 医学 尾状核 腹侧纹状体 帕金森病 纹状体 多巴胺 内科学 麻醉 内分泌学 多巴胺能 疾病
作者
Takao Nozaki,Kenji Sugiyama,Tetsuya Asakawa,Hiroki Namba,Masamichi Yokokura,Tatsuhiro Terada,Tomoyasu Bunai,Yasuomi Ouchi
出处
期刊:Journal of Neurosurgery [American Association of Neurological Surgeons]
卷期号:137 (2): 468-478 被引量:2
标识
DOI:10.3171/2021.10.jns211364
摘要

Subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease is effective; however, its mechanism is unclear. To investigate the degree of neuronal terminal survival after STN-DBS, the authors examined the striatal dopamine transporter levels before and after treatment in association with clinical improvement using PET with [11C]2β-carbomethoxy-3β-(4-fluorophenyl)tropane ([11C]CFT).Ten patients with Parkinson's disease who had undergone bilateral STN-DBS were scanned twice with [11C]CFT PET just before and 1 year after surgery. Correlation analysis was conducted between [11C]CFT binding and off-period Unified Parkinson's Disease Rating Scale (UPDRS) scores assessed preoperatively and postoperatively.[11C]CFT uptake reduced significantly in the posterodorsal putamen contralateral to the parkinsonism-dominant side after 1 year; however, an increase was noted in the contralateral anteroventral putamen and ipsilateral ventral caudate postoperatively (p < 0.05). The percentage increase in [11C]CFT binding was inversely correlated with the preoperative binding level in the bilateral anteroventral putamen, ipsilateral ventral caudate, contralateral anterodorsal putamen, contralateral posteroventral putamen, and contralateral nucleus accumbens. The percentage reduction in UPDRS-II score was significantly correlated with the percentage increase in [11C]CFT binding in the ipsilateral anteroventral putamen (p < 0.05). The percentage reduction in UPDRS-III score was significantly correlated with the percentage increase in [11C]CFT binding in the ipsilateral anteroventral putamen, ventral caudate, and nucleus accumbens (p < 0.05).STN-DBS increases dopamine transporter levels in the anteroventral striatum, which is correlated with the motor recovery and possibly suggests the neuromodulatory effect of STN-DBS on dopaminergic terminals in Parkinson's disease patients. A preoperative level of anterior striatal dopamine transporter may predict reserve capacity of STN-DBS on motor recovery.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
羞涩的文轩完成签到 ,获得积分10
刚刚
5秒前
6秒前
北城完成签到 ,获得积分10
8秒前
量子星尘发布了新的文献求助10
8秒前
11秒前
爱听歌电灯胆完成签到 ,获得积分10
11秒前
不爱吃西葫芦完成签到 ,获得积分10
12秒前
申燕婷完成签到 ,获得积分10
13秒前
橙子完成签到 ,获得积分10
15秒前
ruochenzu发布了新的文献求助10
15秒前
fusheng完成签到 ,获得积分10
24秒前
浮生完成签到 ,获得积分10
29秒前
xinjie完成签到,获得积分10
31秒前
Will完成签到,获得积分10
36秒前
cuddly完成签到 ,获得积分10
37秒前
掉头发的小白完成签到,获得积分10
38秒前
不想看文献完成签到 ,获得积分10
41秒前
42秒前
当女遇到乔完成签到 ,获得积分10
42秒前
独行者完成签到,获得积分10
43秒前
眼睛大的电脑完成签到,获得积分10
43秒前
45秒前
敏敏发布了新的文献求助10
46秒前
木木完成签到 ,获得积分10
47秒前
量子星尘发布了新的文献求助10
47秒前
JamesPei应助科研通管家采纳,获得10
48秒前
彭于晏应助科研通管家采纳,获得10
48秒前
如意2023完成签到 ,获得积分10
48秒前
fomo完成签到,获得积分10
52秒前
nagi发布了新的文献求助10
55秒前
jfeng完成签到,获得积分10
57秒前
JN完成签到,获得积分10
1分钟前
忐忑的书桃完成签到 ,获得积分10
1分钟前
qaplay完成签到 ,获得积分0
1分钟前
友好语风完成签到,获得积分10
1分钟前
CLTTTt完成签到,获得积分10
1分钟前
yk完成签到,获得积分10
1分钟前
甜美的初蓝完成签到 ,获得积分10
1分钟前
早安完成签到 ,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038066
求助须知:如何正确求助?哪些是违规求助? 3575779
关于积分的说明 11373801
捐赠科研通 3305584
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022