聚合
二乙炔
生物物理学
内化
细胞内
化学
两亲性
细胞
材料科学
聚合物
生物化学
共聚物
有机化学
生物
作者
Niannian Lv,Teng Ma,Huimin Qin,Zhuoran Yang,Yanggui Wu,Danqi Li,Juan Tao,Hao Jiang,Jintao Zhu
标识
DOI:10.1007/s40843-022-2008-1
摘要
Recently, in-situ polymerization inside living cells has attracted much attention due to the efficient cellular internalization and elevated drug retention. However, the lack of tracking of the in-situ polymerization process and the unclear effects of polymerization on cellular functions restrict its biomedical applications. Herein, we designed a Y-shaped diacetylene-containing lipidated peptide amphiphile (Y-DLPA1) with positive charges, which underwent in-situ polymerization initiated by reactive oxygen species in the intracellular microenvironment. In comparison, zwitterionic Y-DLPA2 and negatively charged Y-DLPA3 were polymerized in aqueous solution, but cannot polymerize in the intracellular microenvironment. The polymerized Y-DLPA1 with red fluorescence provides a platform to label cells for long-term tracking studies. This polymerization reaction induced tumor cell apoptosis, increased cell viscosity and decreased cell motility, which potentially inhibited tumor metastasis and served as a novel antitumor agent. This work provides a novel strategy to track in-situ polymerization process and modulate cell biofunctions.
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