Lithium Amides as Homochiral Ammonia Equivalents for Conjugate Additions to α,β-Unsaturated Esters: Asymmetric Synthesis of (S)-β-Leucine

Abstract t ‐Butyl diethylphosphonacetate Methylmagnesium bromide Isobutyraldehyde t ‐Butyl ( E )‐4‐methylbut‐2‐enoate R ‐alpha‐Methylbenzylamine R‐N ‐Benzyl‐ N ‐(a‐methylbenzyl)amine Butyllithium t ‐Butyl 3[ N‐ benzyl‐N‐(a‐methylbenzyl)amine]‐4‐methylpentanoate Palladium hydroxide on carbon t ‐Butyl‐3‐amino‐4‐methylpentanoate Trifluoracetic acid ( S )‐3‐Amino‐4‐methylpentanoic acid ( S )‐3‐[ N ‐( p ‐Toluenesulfonyl)amino}‐4‐methylpentanoic acid