Metabolic heterogeneity in rabbit brain glycogen

Glycogen has been carefully isolated from rabbit brain tissue and found to be of significantly greater molecular size (up to approx. 100 MDa) and heterogeneity than previously reported. The incorporation of radioisotope from glucose, pyruvate or acetate precursor has been shown to be non-uniform, being similar to the metabolic inhomogeneity observed in other tissues. Physicochemical studies have shown the gross hydrodynamic structure of the glycogen to be inhomogeneous and to differ significantly from that of liver glycogen.