Amplified Detection of DNA through an Autocatalytic and Catabolic DNAzyme‐Mediated Process

Angewandte Chemie International EditionVolume 50, Issue 1 p. 295-299 Communication Amplified Detection of DNA through an Autocatalytic and Catabolic DNAzyme-Mediated Process† Dr. Fuan Wang, Dr. Fuan Wang Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel), Fax: (+972) 2652-7715Search for more papers by this authorJohann Elbaz, Johann Elbaz Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel), Fax: (+972) 2652-7715Search for more papers by this authorDr. Carsten Teller, Dr. Carsten Teller Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel), Fax: (+972) 2652-7715Search for more papers by this authorProf. Itamar Willner, Corresponding Author Prof. Itamar Willner willnea@vms.huji.ac.il Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel), Fax: (+972) 2652-7715Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel), Fax: (+972) 2652-7715Search for more papers by this author Dr. Fuan Wang, Dr. Fuan Wang Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel), Fax: (+972) 2652-7715Search for more papers by this authorJohann Elbaz, Johann Elbaz Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel), Fax: (+972) 2652-7715Search for more papers by this authorDr. Carsten Teller, Dr. Carsten Teller Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel), Fax: (+972) 2652-7715Search for more papers by this authorProf. Itamar Willner, Corresponding Author Prof. Itamar Willner willnea@vms.huji.ac.il Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel), Fax: (+972) 2652-7715Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904 (Israel), Fax: (+972) 2652-7715Search for more papers by this author First published: 16 November 2010 https://doi.org/10.1002/anie.201005246Citations: 179 † Financial support by the EU ECCell project, the Israel Science Foundation (Converging Technologies fellowship to J.E.), and the Minerva foundation (postdoctoral fellowship to C.T.) is gratefully acknowledged. We thank Prof. G. von Kiedrowski for helpful comments. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract Sense and sensibility: Amplified DNA detection is accomplished by the autocatalytic cleavage of a programmed nucleic acid structure based on the Mg2+-dependent DNAzyme E6 (see picture). The analyte sequence is autocatalytically generated by the DNAzyme from a reporter nucleic acid, which is labeled with a fluorophore and quencher at its two ends. Citing Literature Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description anie_201005246_sm_miscellaneous_information.pdf171.5 KB miscellaneous_information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume50, Issue1January 3, 2011Pages 295-299 RelatedInformation